We explored the effectiveness of Evinacumab, a monoclonal antibody recently approved for treating severe high cholesterol. Our focus was on a 16-year-old girl from North India diagnosed with homozygous familial hypercholesterolemia (HoFH) at the tender age of two. Despite her long-standing battle with high cholesterol, traditional treatments, including medications and lifestyle changes, failed to bring her cholesterol levels down to the recommended guidelines.
Genetic testing confirmed that she had a significant mutation affecting her LDL receptor, contributing heavily to her condition. Her LDL cholesterol levels hovered around 320 mg/dL even after trying the maximum doses of established medications. As her health deteriorated, necessitating aortic valve replacement surgery, we introduced Evinacumab into her treatment regimen. What we observed was truly remarkable; her LDL cholesterol dropped by over 76%, reaching a level of 82 mg/dL that has remained stable over the last four months.
This case highlights Evinacumab as a promising option for managing patients with HoFH, especially for those who have not responded to existing therapies. This was also the first instance of a child in India receiving Evinacumab for this condition, potentially setting a precedent for future treatments.
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Potential atheroprotective effects of T3Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis.
High relevance due to significant findings
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
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We investigated how a high cholesterol diet impacts male fertility by activating stress in testicular cells, leading to cell death. Using rabbits as our model, we found that this diet noticeably increased apoptosis in the testicular tubules. However, when we supplemented the rabbits' diets with α-tocopherol, a form of vitamin E, we observed a remarkable reduction in this cholesterol-induced cell death. This suggests that vitamin E might serve as a protective agent against damage caused by high cholesterol, helping to preserve testicular health.
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Tocopheryl quinone benefits high cholesterolTocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) restoring the balance of intestinal flora in rats.
Moderate relevance for human health
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
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Vitamin E mitigates NASH inflammationalpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis.
High relevance to NASH mechanisms
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
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